Which GLP-1 Should I Take?

Which GLP-1
Should I Take?

If you’ve tried everything and nothing has worked, GLP-1 medications may finally make weight loss feel more realistic. They work by changing hunger, fullness, and appetite signals. But not every option fits the same situation. This page will help you understand which GLP-1 may make the most sense for you.

The side-by-side comparison

A quick look at all six options so you can see how they stack up before diving deeper.

Factor	Mounjaro	Zepbound	Tirzepatide (Compounded)	Ozempic	Wegovy	Semaglutide (Compounded)
Main Ingredient	Tirzepatide	Tirzepatide	Tirzepatide	Semaglutide	Semaglutide	Semaglutide
Approved For	Type 2 Diabetes + Weight loss	Weight loss + sleep apnea in adults with obesity	Provider-guided weight loss use	Type 2 diabetes + heart risk reduction (and kidney benefit for some)	Weight loss + heart risk reduction in certain adults	Provider-guided weight loss use
Expected Weight Loss	Many people lose weight, results vary	High in studies, often 15% to 20%+	Varies by dose and individual	Moderate, about 7 to 14 lbs in studies	High, about 15% body weight in studies	Varies by dose and individual
Monthly Cost	~$1,080 without insurance, as low as $25 with eligible insurance	~$1,086 list price, from ~$299 self-pay, as low as $25 with eligible insurance	~$299–$449	~$935–$1,000 without insurance, as low as $25 with eligible insurance	~$1,349 list price, from ~$199 direct, as low as $25 with eligible insurance	~$200–$500
Best For	People with type 2 diabetes who also want weight support	People focused mainly on weight loss who want the strongest option	People who want lower-cost tirzepatide with provider guidance	People with type 2 diabetes who want blood sugar and heart support	People focused on long-term weight loss with strong study results	People looking for a lower-cost semaglutide option with provider guidance

Not sure where to start? If your main goal is weight loss, Zepbound or tirzepatide are usually the first options to look at. If you have type 2 diabetes, Mounjaro or Ozempic may make more sense. If cost matters most, tirzepatide or semaglutide may be worth discussing.

A closer look at each option

Here is how I would explain each medication to someone who is new to GLP-1s and wants a clear answer.

Please note: Ratings are based on clinical data and client outcomes. Individual results vary. Always work with a provider before starting.

Most Recommended

Tirzepatide

If you are not sure where to start, this is usually the first option to consider. Tirzepatide is the medication used in Mounjaro and Zepbound. It works on two body signals that affect hunger, fullness, and blood sugar. Many people choose this option for strong results and lower cost. The key is working with a provider who can guide you properly.

Mounjaro and Zepbound both use tirzepatide. The difference is how they are prescribed and what they are approved for.

Many people choose this option because it costs less. The key is working with a provider who can guide dosing and monitor your progress.

Yossi's Rating