Lilly Direct

Starting price: $299/mo for Zepbound 2.5 mg
Ongoing cost: Varies by dose, with higher doses costing more

The most direct way to get authentic Zepbound is through Eli Lilly’s official access pathway. This is a strong option if you want FDA-approved medication, transparent pricing, and no compounding. The starting dose is more affordable than many people expect, but higher doses cost more, so patients should check the exact cost before starting. Zepbound is powerful, but the medication alone is not the full plan. Pairing it with proper dietary guidance, side effect management, and long-term weight maintenance support can make a major difference.

Yossi's Rating

Safety 9/10
Transparency 9/10
Trust 9/10
Support 7/10
Cost 7/10

Big Easy Weight Loss

Starting price: $499 for a 10- to 12-week package, depending on treatment
Ongoing cost: Package pricing varies by treatment, pharmacy, and length

A more transparent compounded provider than many others, with package-style pricing instead of a simple month-to-month model. The upfront cost is higher, but the package may be easier to understand for patients who want to know the full cost before starting. Doctor consultations are part of the process, and the company is more open than many competitors about treatment structure. Confirm pharmacy partner, state availability, refill process, and total cost before signing up.

Yossi's Rating

Safety 7/10
Transparency 8/10
Trust 8/10
Support 7/10
Cost 8/10

Lavender Sky Health

Starting price: Medication pricing varies by pharmacy and plan, plus consult fees
Ongoing cost: Varies by pharmacy, medication, dose, and supply length

Best suited for patients who already understand GLP-1 treatment and want more pharmacy flexibility. Lavender Sky Health has lower-cost options, but the pricing is more complicated than a simple monthly program because consult fees and medication costs are separate, and medication pricing varies by pharmacy and dose. This is not the simplest option for someone brand new to GLP-1s. Patients should confirm the exact pharmacy, total upfront cost, refill rules, and support expectations before starting.

Yossi's Rating

Safety 7/10
Transparency 7/10
Trust 7/10
Support 7/10
Cost 8/10

Mochi Health

Starting price: $178/mo for membership + compounded semaglutide
Ongoing cost: $178/mo for compounded semaglutide; higher if using tirzepatide or brand-name medication

One of the more complete compounded GLP-1 programs available. Mochi includes access to a provider, dietitian support, nutrition coaching, and customer support through its membership. The pricing is predictable for compounded semaglutide because the medication cost stays flat across doses. A strong fit if you want lower-cost access with more support than many basic telehealth programs. As with any compounded provider, confirm the pharmacy, dosing instructions, refill process, and current policies before starting.

Yossi's Rating

Safety 7/10
Transparency 8/10
Trust 7/10
Support 8/10
Cost 9/10

Ro

Starting price: $39 first month for the care membership, plus medication cost
Ongoing cost: $149/mo for monthly membership, or as low as $74/mo with annual prepay, plus medication cost

A well-known telehealth program with access to FDA-approved GLP-1 medications and help navigating insurance. The biggest thing to understand is that the membership and medication are billed separately, so the real monthly cost can be much higher than the headline membership price. Ro may be a good fit if you want a structured online program, insurance support, and access to branded medication options. Just make sure you understand the full cost before committing

Yossi's Rating

Safety 8/10
Transparency 8/10
Trust 8/10
Support 8/10
Cost 7/10

GoodRx Care Direct

Starting price:  About $268/mo with care fee + lowest listed medication option
Ongoing cost: About $268+/mo, depending on medication, dose, insurance, and current savings offers

A simple telehealth option focused on access to FDA-approved GLP-1 medications. GoodRx is best for someone who wants a straightforward prescription pathway, clear medication options, and the ability to compare pricing. The cost depends heavily on which medication you use, whether a manufacturer savings offer applies, and whether you are using insurance or paying cash. A good no-frills option, but not the most hands-on program.

Yossi's Rating

Safety 8/10
Transparency 8/10
Trust 8/10
Support 7/10
Cost 7/10

Orderly Meds

Starting price: $224 for 3 months of compounded semaglutide, which comes out to about $74/mo for the starter offer

Ongoing cost: $149/mo for compounded semaglutide after the starter offer

One of the more affordable compounded semaglutide options, especially for new patients using the starter pricing. Orderly Meds keeps the pricing relatively simple and includes the provider review, medication, supplies, and shipping. The main thing to watch is that the lowest price is usually tied to a starter offer, while the ongoing monthly price is higher. As with any compounded provider, confirm the pharmacy partner, lab policy, refill process, and whether the price changes by dose before starting.

Yossi's Rating

Safety 7/10
Transparency 7/10
Trust 7/10
Support 7/10
Cost 9/10

Success by Sesame

Starting price: About $208/mo with annual care pricing + lowest self-pay medication
Ongoing cost: About $208+/mo, depending on care plan, medication, dose, and insurance

A flexible telehealth marketplace with access to providers and weight-loss medication options. Sesame can be a good fit for patients who want more choice and do not want to be locked into one specific provider model. The final cost depends on the care plan, provider, medication, and pharmacy pathway. Before starting, confirm whether the medication is FDA-approved or compounded, what the care fee includes, and what the total monthly cost will be after the first month.

Yossi's Rating

Safety 7/10
Transparency 6/10
Trust 7/10
Support 7/10
Cost 7/10

Walgreens

Starting price: $49 per visit, plus medication cost
Ongoing cost: $49 per visit when needed, plus medication cost

A familiar and reliable option for people who want access to FDA-approved GLP-1 medications without a monthly subscription. Walgreens offers virtual clinician visits, and the medication cost is separate from the visit fee. This can be a good option for self-pay patients who want a simple, recognizable pharmacy-based pathway with a low starting cost. It is not a full coaching program, so patients may still benefit from separate dietitian support.

Yossi's Rating

Safety 9/10
Transparency 9/10
Trust 9/10
Support 7/10
Cost 7/10

Novo Care 

Starting price: $199/mo for eligible new patients 
Ongoing cost: $349/mo for most doses; $399/mo for the highest dose

If you want authentic, FDA-approved Wegovy directly through Novo Nordisk’s official access program, this is one of the clearest options. The $199 intro pricing applies only to eligible new patients and only for the lower starting doses for a limited number of fills. After that, most patients move to the regular cash-pay pricing. This is a strong option if medication authenticity and transparency matter most. Working with a dietitian alongside the medication can make a major difference in results and long-term success.

Yossi's Rating

Safety 9/10
Transparency 9/10
Trust 9/10
Support 7/10
Cost 8/10

MEDVi

Starting price: $179 first month for compounded semaglutide

Ongoing cost: $299/mo for refills

A straightforward option for people who want compounded semaglutide without a separate membership fee. The first month includes the provider review, personalized plan, guidance, medication, and shipping. The main concern is that MEDVi has had recent FDA scrutiny around misleading compounded GLP-1 marketing claims, so this is not a provider I would present as highly trusted. It may still be a lower-entry-cost option, but patients should be careful to confirm the exact medication, pharmacy, dosing instructions, refund rules, and ongoing monthly cost before signing up.

Yossi's Rating

Safety 7/10
Transparency 7/10
Trust 7/10
Support 7/10
Cost 8/10